Father: Zeke McMillan
Sibling: Anthony
Significant Romantic Relationships: Roger Smythe , Frank Hubbard, Tad Martin

Simone arrived in Pine Valley in 2001 at the behest of Edmund Grey in order to aid his brother-in-law Mateo Santos uncover the identity of the drug lord Proteus. An investigative reporter, Simone worked to find Proteus's true identity while pretending to be engaged in an affair with Mateo, in order to protect the latter's wife and son from Proteus's wrath. Simone fell in love with Mateo, but it was clear that his heart lay with his wife. Simone mistakenly believed that a legitimate book publisher was interested in her authoring a book on the investigation. Revealing inside information to the publisher, Simone was shocked when it turned out to be a front set up by Vanessa Cortlandt, the real Proteus. As a result of Simone's leak, FBI agent Chris Stamp was almost killed. A furious Mateo distanced himself from Simone.

Simone moved into the same building as Greenlee Smythe, and Greenlee and Simone became friends. While Greenlee was preparing for her wedding to Leo, she asked Simone to be her maid of honor, while her oft-estranged father, Roger, would walk her down the aisle. Simone was keeping a secret from her friend though: she was having an affair with Roger, who as far as Greenlee knew, was still married to her mother, Mary. While continuing to hide her affair, Simone took on a job as Greenlee's campaign writer/assistant at a cosmetics firm. A guilty Simone tried repeatedly to confess to Greenlee about the affair, but was always interrupted. Guilty over betraying Greenlee, Simone eventually ended her affair with Roger, though her feelings were still there.

Roger was shot on Greenlee and Leo's wedding day and while still alive, he accidentally told Greenlee about his and Simone's affair. A furious Greenlee ended their friendship immediately. Roger died shortly after, and Simone spent months trying to fix her friendship with Greenlee.

Devastated at the turn of events, Simone was hospitalized after drinking too much alcohol and taking pills. She was treated at Pine Valley Hospital by Frank Hubbard, and the two soon began a relationship. It was revealed that Simone's brother, Anthony, was in a coma after a drug overdose years earlier. Simone told Frank the story and he became troubled and distant from her. Simone's estranged father Zeke showed Simone a videotape of her brother's overdose and Frank confessed that he actually shot that tape back when he was an overzealous film student. Furious that Frank didn't try to save her brother, Simone broke up with Frank, and he eventually left town.

Miserable about another relationship gone wrong, Simone was once again at the bar, but this time she overheard Kendall Hart and Greenlee putting plans together for a new cosmetics company. At Kendall's insistence, a reluctant Greenlee agreed that Simone be in charge of publicity for the startup company.

While working together at Fusion, the fences slowly began to mend between Greenlee and Simone. Simone proved to be good at her publicist job as well. Though her publicity stunts often landed her in jail, Fusion became a known cosmetic company. Simone became smitten with Fusion's handyman, Carlos Reyes, despite Carlos' obvious feelings for Greenlee. Simone eventually moved past her feelings and the two became friends.

Simone began a "strictly casual" sexual relationship with Tad Martin. Despite her best attempts not to, she fell in love with Tad. Tad sensitively let Simone know that he did not feel the same way, but Simone continued to see him. Seeing Liza Colby and Krystal Carey's interest in Tad only prompted her to fight harder. Eventually, Tad told all three women he was taking a break from romance in an effort to provide an example for his son Jamie.

Simone threw herself into her work, helping to oversee the launch of Fusion's new fragrance, Enchantment. A loyal friend to Greenlee and Kendall with her own quirky worldview, Simone holds out hope she'll find her Prince Charming soon.