Derek Shepherd; scrubbing in; ice cream; tequila
Estranged wives; complicated relationships; sharing her house (sometimes)
Even though relationships were never Meredith's strong point, she finally married her one true love, Derek Shepherd – twice – on a Post-it, as well as in an official ceremony at City Hall.
Considered "royally inbred" by the other interns, Meredith is the daughter of the late, world-renowned surgeon, Dr. Ellis Grey. Meredith and Derek have two children, Zola and Bailey.
Thanks to her last name, Meredith has always had a lot of high expectations and responsibility riding on her shoulders. During the shootings, Meredith witnessed Derek take a bullet to his chest. Their marriage was rocked by the revelation that Meredith had tampered with Derek's Alzheimer's Trial, but the two have since reconciled. After a very scary delivery during the storm, Meredith welcomed her son, Derek Bailey Shepherd, into the world.
Aside from her starring role on Grey's Anatomy, we like to remember Ellen Pompeo as the only non-beer-chugging character on the wildly successful Old School—where she held her own on the big screen alongside comedy heavyweights McHottie Luke Wilson, McDashing Vince Vaughn and McWitty Will Ferrell.
Her ever-so-popular portrayal of Meredith Grey earned Pompeo a Golden Globe nomination in 2007 and countless—perhaps fanatical—fans. Along with her fellow Grey's Anatomy cast members, she also received the 2007 Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Television Drama.
A Boston native, Pompeo made her major studio film debut in Brad Silberling's Moonlight Mile, alongside the McScrumptious Jake Gyllenhaal, Dustin Hoffman and Susan Sarandon. She went on to star in the wildly successful Old School as well as in Steven Spielberg's Catch Me If You Can, opposite the McSexy Leonardo DiCaprio.
Prior to Moonlight Mile, Pompeo had starred in several independent features, including In the Weeds and Coming Soon.