Meredith's patient loses a lot of blood during her surgery. Richard orders the woman to be put on ice to let her body recover before they continue. Meredith wants to press forward now, but ultimately caves. Her colleagues are concerned that emotions are clouding her judgment. After all, this woman has similar injuries to the ones that killed Lexie.

Cristina's patient and her boyfriend are doomsday preppers. They have survival backpacks called "bug-out bags" that are ready to go should all hell break loose. Cristina decides to make her own bug-out bag. She tells Meredith via phone that she's stocking it with tequila. These long distance friends decide they need to stay the night at their respective hospitals with their respective patients. When morning arrives, Cristina learns that the second surgery is a go. As for Meredith, she must call on various friends (and interns) to babysit Zola while trying to keep her patient alive.

The Meredith-Cristina phone chats continue. One needs to determine the right time to operate on her patient while the other strives to find a way to keep her carpool buddy from getting fired. Two surgeries involving two best friends take place simultaneously in two different parts of the country. Tension is high in Meredith's OR as she struggles to find a tear that's causing a leak. Cristina's OR, on the other hand, is sea of calmness as Dr. Thomas methodically operates while continuing to mentor his carpool buddy.

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