News that the Chief is stepping down has more than a few of Seattle Grace’s finest surgeons updating their resume. George becomes a sex machine and, for Callie’s sake, he must be stopped!

Callie is worn out from having non-stop sex with George. She begs Izzie to take over. (Oh, get your mind out of the gutter! She means take over watching out for him.) This perpetual sex thing is just a coping mechanism as he deals with his father’s death. Hey, there are worse ways to cope.

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