Cristina has a heart. We're not speaking figuratively here. She's been tasked with watching an actual beating heart that's been placed in a box until it can be transported to its new recipient. Cristina's less than thrilled at this babysitting gig until Richard informs her that the heart-in-a-box is the key to everything. We have no idea what he means by that. Cristina figures it out though. More on that in a moment.
Jackson bails on a nerve graft surgery because he doesn't want to hang with Mark, who worries about the future of the Plastics Posse. It's a nickname he's hoping will catch on. Jackson…not so much. He meets up with Cristina, who channels the awesomeness of the heart-in-a-box to breakdown her wish list of surgeries. Jackson uses it to realize that he must choose between working with Mark and being with Lexie. Guess who he picks?
Derek is determined to seek out patients who have hopeless cases. He invites Lexie to join him on this exciting new ride. But first she must convince a stubborn patient to consent to an operation. Justine Campbell (guest star Alfre Woodard) is a writer with an aneurysm that's sprung a leak. She won't sign off on surgery until she finishes her latest book.