George, Owen and Callie treat a soldier back from Iraq. Their patient is suffering from some phantom pain in his leg. The soldier wants to have it amputated. This way he can get a prosthetic, start rehab and hopefully get back to the front. Callie wants nothing to do with it, but George is intrigued by the soldier’s dedication. Owen is, of course, supportive as well. Against her better judgment, Callie performs the amputation.
Alex can't believe Izzie has decided against the surgery. "It's not just your life at stake anymore," he shouts. Derek is furious with Cristina for talking Izzie out of the surgery, until Meredith tells him she's the one who talked to Izzie. Meredith tells Derek how her mother wasn't her mother anymore once she got Alzheimer's. Derek insists it's not the same thing. Izzie's condition is treatable. He orders Meredith, as his resident, to talk Izzie into the surgery.