As Izzie deals with the aftershocks of her night of passion with George, her world is rocked once again when the daughter she gave away 11 years ago comes into Seattle Grace.
George promises an exhausted Callie, who's worked all night, that he'll meet her later for coffee. In walks Izzie, carrying a rosary. Alex is surprised she's doing penance and says, "You did something bad." She and George exchange guilty looks. Things get more intense for Izzie when a couple, the Kleins, come in because their adopted daughter has leukemia. The young girl, Hannah, is actually the baby Izzie gave up for adoption 11 years ago. Can you say “curveball?!”