Richard enforces an 80hr rule for the interns 80hrs per week of work and that's it. Meredith is sent home for working too long of a shift. She does laundry and then goes to visit her mother at the nursing home where she finds Derek. Derek wants to help Ellis, but Meredith doesn't want his help. Derek needs Richard to intervene. Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant. Bailey goes to retrieve Denny's heart, taking Cristina along for the ride. Meanwhile George and Addison treat Bex, a young teen hermaphrodite. And the dog proves troublesome to all who dwell at Casa de Interns including Meredith, after he destroys her freshly washed laundry.