GREY'S ANATOMY - "Time Has Come Today" - The doctors of Seattle Grace help Izzie cope with the loss of her fianc, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of "Grey's Anatomy," THURSDAY, SEPTEMBER 21 (9:00-10:01 p.m., ET) on the ABC Television Network. (ABC/RON TOM) PATRICK DEMPSEY, ELLEN POMPEO