On the heels of their encounter with Ghost Rider and battling the Watchdogs to their highest ranks, the Agents of S.H.I.E.L.D. find themselves in their most mind-bending mission yet. The heroes have been plugged into a virtual reality known as "The Framework," created by Dr. Radcliffe and Fitz. They awake to find themselves in an unrecognizable world – a world in which Hydra reigns supreme. What will become of the team as they make their way through this strange new landscape? What friends and foes will they face? And ultimately, will they ever escape and return to their real lives?
Coulson and the team have an encounter with another organization seeking powered people.
The team asks an Asgardian for help unlocking the secrets of the monolith that swallowed Simmons.
Mack, Daisy and Coulson race to keep Lincoln safe; Hunter will do whatever it takes to get revenge.
After Simmons is rescued, she reveals how she fought to survive in harsh surroundings.
May and Hunter pursue Ward and Hydra; Coulson thinks the ATCU could be keeping a big secret.
As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their biggest foes. Meanwhile, Fitz helps Simmons recover information that could lead them back through the portal.
Dangerous facts about the ATCU are discovered; Ward's plans do not go as expected.
A battle between Hydra and S.H.I.E.L.D. will change Coulson's world; Fitz and Coulson take a risk.
The aftermath of Coulson's trip to Maveth has him more determined than ever to shut Hydra down.
After tracking Malick to Russia, Bobby and Hunter become involved in an assassination plot.
A radical group called the Watchdogs plan to eliminate the Inhumans; Simmons makes a discovery.
After Daisy gets a horrifying glimpse of the future, the team tries to prove that fate is not fixed.
The team hunts for information on a new enemy; Malick's secret may destroy his Hydra legacy.
Agent Daisy Johnson brings the Secret Warriors together for a mission that will affect them all.
As Hive draws more Inhumans to his side, Fitz gets a lead that could stop the maniac forever.
In Part 1 of the 2-hour season finale, Hive's master plan is finally revealed.
In Part 2 of the 2-hour finale, S.H.I.E.L.D. continues its showdown with Hive. Who will live, and who will die?