After Agent Coulson and the team escaped the Framework and awakened back in the real world, they battled L.M.D. (Life Model Decoy) AIDA who had become fully human – and given herself multiple Inhuman abilities. After defeating AIDA with the help of Ghost Rider, the team went to a diner to celebrate but were interrupted by a mysterious man who rendered them frozen. Later, Coulson woke up onboard a station... in space.
Coulson will discover that some, but not all, of his S.H.I.E.L.D. colleagues were taken with him and placed onboard a space station. As they come into contact with the vessel's inhabitants, it becomes abundantly clear that something has gone terribly awry. The team must figure out their role, delving deeper into this nightmarish mystery to try to right what has gone incredibly wrong.
Coulson and the team have an encounter with another organization seeking powered people.
The team asks an Asgardian for help unlocking the secrets of the monolith that swallowed Simmons.
Mack, Daisy and Coulson race to keep Lincoln safe; Hunter will do whatever it takes to get revenge.
After Simmons is rescued, she reveals how she fought to survive in harsh surroundings.
May and Hunter pursue Ward and Hydra; Coulson thinks the ATCU could be keeping a big secret.
As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their biggest foes. Meanwhile, Fitz helps Simmons recover information that could lead them back through the portal.
Dangerous facts about the ATCU are discovered; Ward's plans do not go as expected.
A battle between Hydra and S.H.I.E.L.D. will change Coulson's world; Fitz and Coulson take a risk.
The aftermath of Coulson's trip to Maveth has him more determined than ever to shut Hydra down.
After tracking Malick to Russia, Bobby and Hunter become involved in an assassination plot.
A radical group called the Watchdogs plan to eliminate the Inhumans; Simmons makes a discovery.
After Daisy gets a horrifying glimpse of the future, the team tries to prove that fate is not fixed.
The team hunts for information on a new enemy; Malick's secret may destroy his Hydra legacy.
Agent Daisy Johnson brings the Secret Warriors together for a mission that will affect them all.
As Hive draws more Inhumans to his side, Fitz gets a lead that could stop the maniac forever.
In Part 1 of the 2-hour season finale, Hive's master plan is finally revealed.
In Part 2 of the 2-hour finale, S.H.I.E.L.D. continues its showdown with Hive. Who will live, and who will die?