Fast-thinking trauma surgeon Ziad Sifri can't believe his eyes when a 19-year-old plane crash survivor arrives in the ER. As a third year urology resident, Ashley Winter is hopeful that chemotherapy will work wonders on her patient's cancer-filled bladder, but quickly learns he will need a life-altering surgery. A cardiac surgeon at the top of his game, Leonard Girardi, meets a mother of three who was sent home to die when a top hospital decided the tumor on her heart was inoperable. Dr. Girardi attempts the surgery that others say is impossible. Surgeon Dr. Oz is back in the operating room to deal with a perplexing case of a motorcycle cop who suffers a mysterious stroke while on vacation with his family.