The doctors of Grey Sloan Memorial Hospital Meredith Grey are faced with life-or-death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.
Following a plane crash, the doctors of Seattle Grace try to cope with loss, adapt to changes and move forward with their lives.
The doctors try to cope with heartache and injuries caused by the plane crash; everyone at Seattle Grace struggles to return to normalcy amid the chaos.
The crash survivors must make a life-changing decision; tensions escalate between Jackson and April; Alex tries to restrain himself.
Out of consideration for Derek, Meredith stops talking about her surgeries; Richard asks Dr. Avery to help with a complicated procedure; Callie and Alex face their guilt.
Meredith and Cristina rely on each other as they cope with increasing responsibilities at their respective hospitals and cope with life after the plane crash; Cristina helps Dr. Thomas with a challenging heart surgery.
As the doctors move forward with their lawsuit, they must face the realities of their injuries; Bailey tricks Arizona into assisting with a pediatric case; Cristina seeks normalcy in her new environment.
Owen and Cristina navigate their relationship amid the pending lawsuit; Bailey and Ben argue over wedding plans; while Jackson is distracted by a shocking situation with April, Callie asks him for help fixing Derek's hand.
Meredith asks Heather to help fix Derek's hand; Cristina sets Stephanie and Leah against each other in a competition; Alex starts to see Jo differently; Shane learns a valuable lesson from April.
While the doctors prepare for Bailey's wedding, Richard helps her with her anxiety; Lizzie and Meredith butt heads; Callie and Jackson try to get Derek to submit to a risky surgery for his hand.
Bailey continues to put her wedding day on hold as she tries to save Adele's life; Owen and Cristina are unsure about their pending divorce; Callie and Arizona try to reignite their spark.
Derek, Meredith, Arizona and Cristina receive news about the plane crash lawsuit; Richard avoids Catherine's advances; Jackson takes on one of Mark Sloane's former patients.
A new doctor at Seattle Grace puts others on edge; Arizona struggles with phantom limb pain; Meredith is faced with her worst fear.
Derek and April fight to find a solution for the hospital; Cristina works to respect the wishes of a dying boy's family; Arizona identifies with a teenager who is facing similar problems.
Several of the doctors compete to be the new face of Seattle Grace; April brings an emergency case to the hospital; Alex and Jackson work with a transgender teen couple; new policies test the patience of the staff.
Owen is faced with tough decisions as Seattle Grace spirals toward financial ruin; Jo and Alex try to save an infant's life; April turns to Jackson for dating advice.
As news of Seattle Grace's financial issues spreads, Catherine wants Jackson to move to Boston and the interns fear for their jobs; the doctors try to save the hospital by meeting with a possible investor; Jo is impressed with Alex.
Discord and chaos created by new management causes one doctor to question his future at Seattle Grace; the doctors and interns juggle multiple transplant surgeries simultaneously.
More positive changes are made by the hospital's new management; Meredith worries about her unborn baby; Alex decides to give Jo's boyfriend a run for his money.
A gas tanker explodes on a highway, resulting in multiple injuries; Jo and Meredith try to help a frantic woman, whose child has a mysterious illness; Alex is forced to work with Jo's boyfriend.
Unsettling news motivates Derek and Meredith to take preventive steps for their children's future; Syrian doctors come to the hospital for a crash course in basic surgical skills; April decides to tell Matthew the truth.
After several of Bailey's patients die, she becomes the focus of a CDC investigation; Cristina teases Alex about his feelings for Jo; Owen continues to take care of Ethan while his parents remain in the hospital.
Bailey continues to shut everyone out; Owen worries that Ethan could end up in foster care; a new craniofacial specialist comes to the hospital to work on a young patient; a magician's assistant needs medical attention after a trick goes awry.
The doctors prepare for a superstorm headed for Seattle; as Owen becomes closer to Ethan, his desire to be a parent gets stronger; Meredith and her baby are put in danger.
As the storm rages, patients are brought to the hospital by the busload and resources dwindle; a doctor's life hangs in the balance.