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Jimmy Kimmel Live airs every weeknight at 11:35 p.m. EDT and features a diverse lineup of guests that includes celebrities, athletes, musical acts, comedians and human-interest subjects, along with comedy bits and a house band. 

ABC's Jimmy Kimmel Live! welcomes guest hosts this week. Jimmy's son, Billy, had a scheduled and successful heart surgery this morning.  

While Jimmy is with his family, these celebrity Samaritans will handle hosting duties.

Monday, Dec. 4
Guest host: Chris Pratt
Guest: Margot Robbie ("I, Tonya")
Musical guest: Chris Stapleton

Tuesday, Dec. 5
Guest host: Tracee Ellis Ross
Guests: Mary J. Blige ("Mudbound"), Amanda de Cadenet
Musical guest: Miguel featuring Travis Scott

Wednesday, Dec. 6
Guest host: Neil Patrick Harris
Guests: Armie Hammer & Timothée Chalamet ("Call Me By Your Name"), Vanessa Kirby ("The Crown"), Wildlife Expert Jules Sylvester with animals

Thursday, Dec. 7
Guest host: Melissa McCarthy
Guests: Octavia Spencer ("The Shape of Water"), Actor Dave Franco ("The Disaster Artist")
Musical guest: Hanson

Friday, Dec. 8 (Originally Aired 12/4)
Guest host: Chris Pratt
Guest: Margot Robbie ("I, Tonya")
Musical guest: Chris Stapleton