After Agent Coulson and the team escaped the Framework and awakened back in the real world, they battled L.M.D. (Life Model Decoy) AIDA who had become fully human – and given herself multiple Inhuman abilities. After defeating AIDA with the help of Ghost Rider, the team went to a diner to celebrate but were interrupted by a mysterious man who rendered them frozen. Later, Coulson woke up onboard a station... in space.
Coulson will discover that some, but not all, of his S.H.I.E.L.D. colleagues were taken with him and placed onboard a space station. As they come into contact with the vessel's inhabitants, it becomes abundantly clear that something has gone terribly awry. The team must figure out their role, delving deeper into this nightmarish mystery to try to right what has gone incredibly wrong.
Running out of options, Coulson's only hope at saving his team is to put them in the line of fire.
Coulson and his team race against Hydra to find a man with the ability to freeze objects.
While Coulson tries to learn more about the mysterious writing, Melinda May attacks him.
Coulson and the team are faced with Hydra's security chief -- the beautiful, deadly Bobbi Morse.
While impersonating S.H.I.E.L.D., Hydra orchestrates a devastating attack on the United Nations.
Coulson's etchings lead the team to several murder victims; lies and secrets come to a head.
Coulson and the team face off against Hydra as they try to uncover an ancient secret.
S.H.I.E.L.D. discovers the ancient city but uncovering the secrets may require a major sacrifice.
An explosive confrontation changes everyone's fate; Skye uncovers secrets about her past.
Coulson and the team help Lady Sif, who lost her memory after a fight with a mysterious warrior.
A shocking revelation and an impending decision leaves the team broken.
As stunning revelations are brought to light, war comes to Coulson in a way he did not expect.
After Robert Gonzales takes action, Coulson fights to protect the future of S.H.I.E.L.D.
The story of Melinda's transformation is revealed; Skye learns more about her heritage.
Gonzales and Coulson fight to put aside their differences as they work with an untrustworthy ally.
As tensions rise between S.H.I.E.L.D. and Inhumans, Skye finds herself torn between the groups.
In part one of the season finale, the Inhumans' endgame is revealed.
In part two of the season finale, the Inhumans' endgame is revealed.